Denigma: Factor

Adcy5

Symbol: Adcy5
Name: adenylate cyclase 5
Alias: AC5
Entrez gene ID: 224129
Ensembl gene ID: ENSMUSG00000022840
Species: Mouse (Taxid: 10090)

Functional description:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase. [UniProt]

Observation:

Adcy5 knockout mice are to cardiac stress and have an increased median lifespan of 30% as well as an increased maximal lifespan of 12%. Further, they are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function [17662940].

Interventions:

Adcy5 knockout +30% +12%

Assays: Organismal Lifespan
Median: +30
Maximum: +12

Classification:

Gerontogene

Positive Gerontogene

References:

17662940: Type 5 adenylyl cyclase disruption increases longevity and protects against stress.

Aging Relevance Analysis/Source:

GenAge