sgk-1

Symbol: sgk-1
Name: Serum- and Glucocorticoid- inducible kinase homolog
Entrez gene ID: 181697
Ensembl gene ID: W10G6.2
Species: Worm (Taxid: 6239)

Functional description:
SGK-1 acts in parallel to the AKT kinases to mediate DAF-2 signalling; Acts downstream of age-1 and pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Does not appear to play a role in immune function. [UniProt]

Observation:

Inhibition of sgk-1 activity by RNAi results in an lifespan extension by approximately 60% which is suppressed by mutation of daf-16 [15068796].

Inactivation of sgk-1 either by mutation or RNAi results in animals that have severe a egg-laying defect, extended generation time, increased stress resistance, i.e. pleitropic phenotypes similar to mutants in daf-2, age-1, and pdk-1 [15068796].



Interventions:
  • sgk-1 RNAi +63%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SGK1 (9606)
  • SGK1 (9615)
  • SGK1 (9913)
  • Sgk1 (10090)
  • Sgk1 (10116)
  • SGK1 (9031)
  • sgk1 (7955)
  • sgk-1 (6239)



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