SdhB

Symbol: SdhB
Name: Succinate dehydrogenase B
Entrez gene ID: 35590
Ensembl gene ID: FBgn0014028
Species: Fly (Taxid: 7227)

Functional description:
Succinate dehydrogenase B; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). [UniProt]

Observation:

SdhB mutants are hypersensitive to oxygen and displays signs of premature aging, including a 66% decrease in mean lifespan and a 17% decrease in maximum lifespan [17056719].



Interventions:
  • SdhB mutation -66% -17%

  • Assays: Organismal Lifespan
    Mean: -66
    Maximum: -17

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 17056719: Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SDHB (9606)
  • SDHB (9598)
  • SDHB (9615)
  • SDHB (9615)
  • SDHB (9913)
  • Sdhb (10090)
  • Sdhb (10116)
  • SDHB (9031)
  • sdhb (7955)
  • SdhB (7227)
  • AgaP_AGAP007309 (7165)
  • sdhb-1 (6239)
  • sdh2 (4896)
  • SDH2 (4932)
  • KLLA0E00683g (28985)
  • AGOS_ACL065C (33169)
  • GeneID:2674556 (148305)
  • NCU00959 (5141)
  • SDH2-3 (3702)
  • Os09g0370300 (4530)

  • Inparanoids
  • FBpp0085489 (7227)
  • ENSMUSP00000010007 (10090)
  • ENSRNOP00000010593 (10116)
  • ENSMMUP00000002161 (9544)
  • ENSP00000364649 (9606)
  • YLL041C (4932)
  • SPAC140.01 (4896)



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