scl-1

Symbol: scl-1
Name: SCP-Like extracellular protein
Entrez gene ID: 186053
Ensembl gene ID: F49E11.9
Species: Worm (Taxid: 6239)

Functional description:
Protein SCL-1; SCP-Like extracellular protein family member (scl-1) [Source:RefSeq peptide;Acc:NP_502502] [Ensembl]; scl-1 encodes a predicted secretory protein that is a member of the cysteine-rich secretory protein (CRISP) family; scl-1 activity positively regulates longevity and stress resistance; in wild-type animals, scl-1 mRNA is detected solely in eggs, while in daf-2 mutants it is detected in eggs and late adult stages; scl-1 expression appears to be under the control of the DAF-2/insulin-like signaling pathway as, in mixed-stage cultures, scl-1 mRNA levels are increased in daf-2 and age-1 mutants and undetectable in daf-16 mutants; scl-1 contains a DAF-16 consensus binding element within its predicted regulatory regions. [WormBase]

Observation:

Downregulation of scl-1 by RNAi reduces slightly but reproducibly lifespan as well as stress resistance, similar to the effect of mutation in daf-16. scl-1 RNAi prevents lifespan extension associated with mutation of daf-2 or age-1. scl-1 contains several DAF-16 consensus binding elements within its predicted regulatory region and is a direct target for transcriptional activation by DAF-16. scl-1 mRNA levels increase highly in daf-2 and age-1 mutation, lowly in wild-type N2 and undetectable in daf-16 mutants. [12620193].

RNAi of scl-1 causes hat shock and UV sensitivity [12620193].



Interventions:
  • scl-1 RNAi

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PI16 (9606)
  • PI16 (9598)
  • PI16 (9615)
  • PI16 (9913)
  • Pi16 (10090)
  • Pi16 (10116)
  • PI16 (9031)
  • scl-5 (6239)
  • vap-1 (6239)
  • scl-15 (6239)
  • scl-17 (6239)
  • scl-3 (6239)
  • scl-18 (6239)
  • scl-2 (6239)
  • scl-9 (6239)
  • scl-13 (6239)
  • scl-10 (6239)
  • scl-23 (6239)
  • scl-12 (6239)
  • scl-11 (6239)
  • scl-14 (6239)
  • scl-6 (6239)
  • scl-1 (6239)
  • scl-7 (6239)
  • scl-8 (6239)
  • scl-20 (6239)
  • scl-19 (6239)
  • scl-22 (6239)
  • scl-21 (6239)
  • AT5G26130 (3702)
  • AT1G50050 (3702)
  • AT1G50060 (3702)
  • AT4G33720 (3702)
  • AT4G33710 (3702)
  • ATPRB1 (3702)
  • PR1 (3702)
  • AT3G19690 (3702)
  • PR-1-LIKE (3702)
  • AT2G19970 (3702)
  • AT2G19980 (3702)



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