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Symbol: sams-1 Name: S-Adenosyl Methionine Synthetase 1 Entrez gene ID: 181370 Ensembl gene ID: C49F5.1 Species: Worm (Taxid: 6239) Functional description: Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity). [UniProt] Observation: sams-1 RNAi significantly extends lifespan of wild-type by 14 - 15%, of daf-16 mutant by 30% and daf-2 by 55%, but fails to significantly further extend lifespan of eat-2 mutants. mRNA level of sams-1 is 2-fold reduced in eat-2 mutants. Like DR, sams-1 RNAi reduces brood size and slightly reproductive timing as well as causes a slender phenotype [16103914]. sams-1 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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