|
Symbol: RTG3 Name: ReTroGrade regulation 3 Entrez gene ID: 852171 Ensembl gene ID: YBL103C Species: Yeast (Taxid: 4932) Functional description: Rtg3p; Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways [Source:SGD;Acc:S000000199] [Ensembl] Observation: RTG3 deletion mutation causes an increase in mean replicative in lifespan by 55% increase at 2% glucose, suggesting that expression of genes regulated by Rtg1-Rtg3 has a negative effect on longevity in 2% glucose (in YPK9). A null mutant has 123% increases mean lifespan at 0.1% glucose relative to a wild-type strain at 2% glucose, indicating that reduced glucose and an RTG3 mutation have an additive effect on lifespan (in YPK9) [11024000]. RTG3 null mutant cannot grow on acetate medium and requires glutamate or aspartate for growth [9032238]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit