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Symbol: RPO41 Name: RNA POlymerase 41 Entrez gene ID: 850507 Ensembl gene ID: YFL036W Species: Yeast (Taxid: 4932) Functional description: Rpo41p; Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; binding of Mtf1p to the Rpo41p-promoter complex stabilizes the binding and ind /.../NA bending [Source:SGD;Acc:S000001858] [Ensembl]; Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; binding of Mtf1p to the Rpo41p-promoter complex stabilizes the binding and induces DNA bending [SGD] Observation: RPO41 mutants exhibit reduced chronological lifespan accompanied by imbalanced mitochondrial translation, conditional inactivation of respiration, elevated production of reactive oxygen species, and increased oxidative stress [16782871]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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