Symbol: RPL31A
Name: Ribosomal Protein of the Large subunit 31A
Alias: RPL34; L31A; L34A; YL28
Entrez gene ID: 851484
Ensembl gene ID: YDL075W
Species: Yeast
(Taxid: 4932)
Functional description:
Rpl31ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality [Source:SGD;Acc:S000002233] [Ensembl]
Observation:
Deletion of RPL31A increases mean replicative lifespan by 45% [16293764]. Mean replicative lifespan increases by 35% in the alpha strain and 50% in a strain [19030232; 18423200]. Mean replicative lifespan of the RPL31A deletion mutant increases by 35% in the ORF collection and by 29% in the remade strain [22377630]. RPL31A deletion increases significantly replicative lifespan [17174052]. Deletion of RPL31A extends replicative lifespan and is not further extended by 0.05% glucose restriction [18423200].
Interventions:
RPL31A deletion
+29 to +50%
Assays:
Replicative Lifespan
Mean: +29-50
Classification:
Gerontogene
Positive Gerontogene
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
LOC459973
(9598)
LOC607833
(9615)
Gm10072
(10090)
LOC681338
(10116)
zgc:136896
(7955)
RpL31
(7227)
AgaP_AGAP011896
(7165)
rpl31
(4896)
RPL31B
(4932)
RPL31A
(4932)
KLLA0B02937g
(28985)
AGOS_AER076C
(33169)
GeneID:2676703
(148305)
NCU08344
(5141)
AT2G19740
(3702)
AT4G26230
(3702)
AT5G56710
(3702)
Os06g0319700
(4530)
Os02g0717800
(4530)
PFE0185c
(5833)
Orthologs
RGD1561195
(10116)
LOC714120
(9544)
RPL31
(9606)
LOC680499
(10116)
RpL31
(7227)
LOC715088
(9544)
Gm8759
(10090)
LOC706340
(9544)
Rpl31
(10116)
LOC100359986
(10116)
rpl-31
(6239)
LOC719029
(9544)
Gm10072
(10090)
LOC714171
(9544)
LOC716358
(9544)
LOC694561
(9544)
LOC695373
(9544)
LOC695247
(9544)
LOC690384
(10116)
Rpl31
(10090)
LOC100504277
(10090)
LOC710744
(9544)
LOC693466
(9544)
LOC696027
(9544)
RGD1562547
(10116)
LOC711041
(9544)
LOC697214
(9544)
RGD1563551
(10116)
LOC100360252
(10116)
rpl31
(4896)
RGD1561841
(10116)
LOC708085
(9544)
LOC100361974
(10116)
RGD1564839
(10116)
LOC681338
(10116)
Gm6635
(10090)
LOC694937
(9544)
RGD1561195
(10116)
LOC714120
(9544)
RPL31
(9606)
LOC680499
(10116)
RpL31
(7227)
LOC715088
(9544)
Gm8759
(10090)
LOC706340
(9544)
Rpl31
(10116)
LOC100359986
(10116)
RPL31B
(4932)
rpl-31
(6239)
LOC719029
(9544)
Gm10072
(10090)
LOC714171
(9544)
LOC716358
(9544)
LOC694561
(9544)
LOC695373
(9544)
LOC695247
(9544)
LOC690384
(10116)
Rpl31
(10090)
LOC100504277
(10090)
LOC710744
(9544)
LOC693466
(9544)
LOC696027
(9544)
RGD1562547
(10116)
LOC711041
(9544)
LOC697214
(9544)
RGD1563551
(10116)
LOC100360252
(10116)
rpl31
(4896)
RGD1561841
(10116)
LOC708085
(9544)
LOC100361974
(10116)
RGD1564839
(10116)
LOC681338
(10116)
Gm6635
(10090)
LOC694937
(9544)
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