Denigma: Factor

rnf-5

Symbol: rnf-5
Name: RiNg Finger protein
Entrez gene ID: 175532
Ensembl gene ID: C16C10.7
Species: Worm (Taxid: 6239)

Functional description:
Protein RNF-5; RING finger protein 5 [Source:UniProtKB/Swiss-Prot;Acc:Q09463] [Ensembl]; rnf-5 encodes a homolog of mammalian RNF5, an E3 ubiquitin ligase; in C. elegans, RNF-5 functions as a ubiquitin ligase that regulates activity of the UNC-95 LIM domain protein that is essential for proper formation of muscle attachment structures; RNF-5 localizes to striated muscle dense bodies, cell junctions, and to the nucleus. [WormBase]

Observation:

RNAi of rnf-5 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808].

Interventions:

rnf-5 RNAi +3% +8%

Assays: Organismal Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge