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Symbol: rcq-5 Name: ReCQ DNA helicase family Entrez gene ID: 175522 Ensembl gene ID: E03A3.2 Species: Worm (Taxid: 6239) Functional description: Protein RCQ-5; ReCQ DNA helicase family member (rcq-5) [Source:RefSeq peptide;Acc:NP_497810] [Ensembl]; rcq-5 encodes an ATP-dependent DNA helicase that is a member of the RecQ family of DNA helicases; loss of rcq-5 activity via RNAi results in decreased lifespan and increased sensitivity to ionizing radiation; RCQ-5, a nuclear protein, is expressed in germ cells and oocytes, as well as in somatic cells from embryogenesis through adulthood, with highest levels of postembryonic expression seen in intestinal cells; mutations in rcq-5 exhibit synthetic lethality in combination with mutations in rtel-1, which encodes a functional analog of yeast Srs2 and vertebrate RTEL1, which negatively regulates homologous recombination. [WormBase] Observation: RNA interference did not appear to affect development but reduced lifespan by 37%. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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