Symbol: rb Name: ruby Entrez gene ID: 31381 Ensembl gene ID: FBgn0003210 Species: Fly (Taxid: 7227) Functional description: ruby; ruby [Source:FlyBase gene name;Acc:FBgn0003210] [Ensembl]; The gene ruby is referred to in FlyBase by the symbol Dmel\rb (CG11427, FBgn0003210). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding; protein transporter activity. There is experimental evidence that it is involved in the biological process: regulation of protein ubiquitination; determination of adult lifespan; negative regulation of gene silencing by RNA; ommochrome biosynthetic process. 18 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; testis pigment cell; secondary pigment cell pigment granule; ocellus pigment granule; tertiary pigment cell pigment granule; photoreceptor cell pigment granule; pigment cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Adaptor protein complex AP-3, beta subunit; Armadillo-like helical; Armadillo-type fold; Clathrin/coatomer adaptor, adaptin-like, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [FlyBase] Observation: Loss-of-function mutation reduces mean lifespan by 33% and maximum lifespan by 22% [17435236]. Interventions: Assays: Organismal Lifespan Mean: -33 Maximum: -22 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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