rb

Symbol: rb
Name: ruby
Entrez gene ID: 31381
Ensembl gene ID: FBgn0003210
Species: Fly (Taxid: 7227)

Functional description:
ruby; ruby [Source:FlyBase gene name;Acc:FBgn0003210] [Ensembl]; The gene ruby is referred to in FlyBase by the symbol Dmel\rb (CG11427, FBgn0003210). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding; protein transporter activity. There is experimental evidence that it is involved in the biological process: regulation of protein ubiquitination; determination of adult lifespan; negative regulation of gene silencing by RNA; ommochrome biosynthetic process. 18 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; testis pigment cell; secondary pigment cell pigment granule; ocellus pigment granule; tertiary pigment cell pigment granule; photoreceptor cell pigment granule; pigment cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Adaptor protein complex AP-3, beta subunit; Armadillo-like helical; Armadillo-type fold; Clathrin/coatomer adaptor, adaptin-like, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [FlyBase]

Observation:

Loss-of-function mutation reduces mean lifespan by 33% and maximum lifespan by 22% [17435236].



Interventions:
  • rb mutation -33% -22%

  • Assays: Organismal Lifespan
    Mean: -33
    Maximum: -22

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AP3B2 (9606)
  • AP3B2 (9598)
  • AP3B2 (9615)
  • Ap3b2 (10090)
  • Ap3b2 (10116)
  • AP3B2 (9031)
  • rb (7227)
  • apb-3 (6239)
  • GeneID:2679413 (148305)
  • NCU06569 (5141)
  • AT3G55480 (3702)
  • Os01g0973300 (4530)

  • Inparanoids
  • FBpp0070670 (7227)
  • ENSMUSP00000080739 (10090)
  • ENSRNOP00000026030 (10116)
  • ENSMMUP00000000831 (9544)
  • ENSP00000255194 (9606)
  • YGR261C (4932)
  • SPAC23H3.06 (4896)



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