Denigma

RAS2

Symbol: RAS2
Name: Ras-like protein 2
Alias: CTN5; CYR3; GLC5; TSL7
Entrez gene ID: 855625
Ensembl gene ID: YNL098C
Species: Yeast (Taxid: 4932)

Functional description:
Ras2p; GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes [Source:SGD;Acc:S000005042] [Ensembl]

Observation:

Overexpression of RAS2 causes a 43% increase in mean and 18% increase in maximum lifespan as well as postpones the age-related increase in generation time. RAS2 deletion causes a 23% decrease in mean and a 30% decrease in maximum lifespan [8034612]. Deletion of RAS2 leads to a longer chronological lifespan [21076178]. Deletion of the RAS2 gene, which functions upstream of CYR1, doubles the mean chronological lifespan by a mechanism that requires Msn2/4 and Sod2 [12586694]. DR further extends chronological lifespan of ras2Delta [18225956].



Interventions:
  • RAS2 deletion -23% -30%
  • RAS2 overexpression +43% +18%

    • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • RRAS2 (9606)
  • RRAS2 (9598)
  • RRAS2 (9615)
  • RRAS2 (9913)
  • Rras2 (10090)
  • Rras2 (10116)
  • RRAS2 (9031)
  • rras2 (7955)
  • Ras64B (7227)
  • AgaP_AGAP002812 (7165)
  • ras-1 (6239)
  • ras1 (4896)
  • RAS2 (4932)
  • RAS1 (4932)
  • KLLA0C13387g (28985)
  • AGOS_ADL262W (33169)
  • GeneID:2684336 (148305)
  • NCU08823 (5141)

    • Orthologs
  • RIT1 (9606)
  • Rit2 (10116)
  • ras-2 (6239)
  • Mras (10116)
  • RRAS2 (9606)
  • MRAS (9606)
  • ras-1 (6239)
  • LOC699700 (9544)
  • Rras (10090)
  • Ric (7227)
  • Rras2 (10116)
  • Rit2 (10090)
  • Rit1 (10090)
  • RRAS (9544)
  • Rit1 (10116)
  • ras1 (4896)
  • RIT2 (9544)
  • RRAS (9606)
  • Ras64B (7227)
  • MRAS (9544)
  • Rras (10116)
  • RIT1 (9544)
  • Rras2 (10090)
  • Mras (10090)
  • RIT2 (9606)
  • RIT1 (9606)
  • Rit2 (10116)
  • ras-2 (6239)
  • Mras (10116)
  • RRAS2 (9606)
  • MRAS (9606)
  • ras-1 (6239)
  • LOC699700 (9544)
  • Rras (10090)
  • Ric (7227)
  • Rras2 (10116)
  • Rit2 (10090)
  • Rit1 (10090)
  • RRAS (9544)
  • Rit1 (10116)
  • ras1 (4896)
  • RIT2 (9544)
  • RRAS (9606)
  • Ras64B (7227)
  • MRAS (9544)
  • Rras (10116)
  • RIT1 (9544)
  • RAS1 (4932)
  • Rras2 (10090)
  • Mras (10090)
  • RIT2 (9606)
  • RIT1 (9606)
  • Rit2 (10116)
  • ras-2 (6239)
  • Mras (10116)
  • RRAS2 (9606)
  • MRAS (9606)
  • ras-1 (6239)
  • RIT1 (9544)
  • Rras (10090)
  • Ric (7227)
  • Rras2 (10116)
  • Rit2 (10090)
  • LOC699700 (9544)
  • Rit1 (10090)
  • RIT2 (9544)
  • Rit1 (10116)



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