sco-1

Symbol: sco-1
Name: SCO (yeast Suppressor of Cytochrome Oxidase deficiency) homolog 1
Entrez gene ID: 173763
Ensembl gene ID: C01F1.2
Species: Worm (Taxid: 6239)

Functional description:
Protein SCO-1; Protein SCO-1 [Source:UniProtKB/TrEMBL;Acc:Q17557] [Ensembl]; sco-1 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the SCO-1 protein is predicted to be mitochondrial with 68% accuracy. C01F1.2 is also homologous to human COX, which when mutated leads to Leigh syndrome (OMIM:256000). Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. [WormBase]

Observation:

RNA interference of sco-1 in adulthood results in a 23% increase in mean lifespan [17521386].



Interventions:
  • sco-1 RNAi +23%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SCO1 (9606)
  • SCO1 (9598)
  • SCO1 (9615)
  • SCO1 (9913)
  • Sco1 (10090)
  • Sco1 (10116)
  • SCO1 (9031)
  • CG8885 (7227)
  • AgaP_AGAP008774 (7165)
  • C01F1.2 (6239)
  • sco1 (4896)
  • SCO1 (4932)
  • KLLA0D03630g (28985)
  • AGOS_AEL191C (33169)
  • GeneID:2682559 (148305)
  • NCU03177 (5141)
  • AT3G08950 (3702)
  • Os02g0159700 (4530)
  • PF07_0034 (5833)



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