RAD52

Symbol: RAD52
Name: RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
Entrez gene ID: 854976
Ensembl gene ID: YML032C
Species: Yeast (Taxid: 4932)

Functional description:
required for repair of nearly all double stranded DNA breaks [8692957]. Targets Rad51 to single-strand DNA [10748203]; Rad52p; Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis [Source:SGD;Acc:S000004494] [Ensembl]

Observation:

Deletion in RAD52 causes a 75% reduction in mean replicative lifespan in PSY316 strain [10207108]. Similiar reduction of lifespan occurs in strains W3031-A and W303R [M. Baeberlein, M. McVey, and L. Guarente, unpublished].

RAD51 is required for formation of extrachromosomal rDNA circles [10207108], but not for replication fork pausing nor DNA breakage with the rDNA [10693764].



Interventions:
  • RAD52 deletion -75%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RAD52 (4932)
  • KLLA0B01782g (28985)
  • AGOS_AER306C (33169)



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