RAD50

Symbol: RAD50
Name: RADiation sensitive 50
Entrez gene ID: 855471
Ensembl gene ID: YNL250W
Species: Yeast (Taxid: 4932)

Functional description:
Rad50p; Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining [Source:SGD;Acc:S000005194] [Ensembl]

Observation:

RAD50 mutations result in a 70% reduced replicative lifespan [10207108].



Interventions:
  • RAD50 deletion -70%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RAD50 (9606)
  • RAD50 (9598)
  • RAD50 (9615)
  • Rad50 (10090)
  • Rad50 (10116)
  • RAD50 (9031)
  • im:6906849 (7955)
  • rad50 (7227)
  • AgaP_AGAP003676 (7165)
  • rad50 (4896)
  • RAD50 (4932)
  • KLLA0C02915g (28985)
  • AGOS_AFR637W (33169)
  • GeneID:5051344 (148305)
  • NCU00901 (5141)
  • RAD50 (3702)
  • Os02g0497500 (4530)
  • PFF0285c (5833)



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