POSH

Symbol: POSH
Name: Plenty of SH3s
Alias: POSH
Entrez gene ID: 36990
Ensembl gene ID: FBgn0040294
Species: Fly (Taxid: 7227)

Functional description:
Plenty of SH3s; Plenty of SH3s [Source:FlyBase gene name;Acc:FBgn0040294] [Ensembl]; The gene Plenty of SH3s is referred to in FlyBase by the symbol Dmel\POSH (CG4909, FBgn0040294). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: protein localization; negative regulation of cell death; determination of adult lifespan; pole plasm oskar mRNA localization; oocyte microtubule cytoskeleton polarization; rhabdomere development. 14 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; genitalia; tarsal segment; wing; melanotic mass; wing hair. It has one annotated transcript and one annotated polypeptide. Protein features are: Neutrophil cytosol factor 2 p67phox; Src homology-3 domain; Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [FlyBase]

Observation:

Neural-specific overexpression of POSH extends the mean lifespan of adult flies by 14% at 25°C. Ectopic expression of POSH during development results in morphological abnormalities [11868902].



Interventions:
  • Neural-specific POSH overexpression +14%

  • Assays: Organismal Lifespan
    Mean: +14

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • References:
  • 11868902: Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SH3RF1 (9606)
  • SH3RF1 (9598)
  • SH3RF1 (9615)
  • SH3RF1 (9913)
  • Sh3rf1 (10090)
  • Sh3rf1 (10116)
  • SH3RF1 (9031)
  • si:dkey-15j16.4 (7955)
  • LOC100329529 (7955)
  • POSH (7227)
  • AgaP_AGAP011487 (7165)

  • Inparanoids
  • FBpp0086007 (7227)
  • ENSMUSP00000034060 (10090)
  • ENSRNOP00000013815 (10116)
  • ENSMMUP00000034555 (9544)
  • ENSP00000284637 (9606)



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