Plau

Symbol: Plau
Name: Plasminogen activator, urokinase
Entrez gene ID: 18792
Ensembl gene ID: ENSMUSG00000021822
Species: Mouse (Taxid: 10090)

Functional description:
Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. [UniProt]

Observation:

Transgenic mice (called alphaMUPA) overexpression Plau in many brain sites (including hypothalamus) consume (20%) less food, have a reduced body weight (by 20%) and length (by 6%), reduced temperature, and a prolonged lifespan (by 20%) [9060969].

alphaMUPA mice have reduced levels of blood sugar and smaller size and birth frequency compared to parental control [9060969] as well as a reduced body weight [10638529].



Interventions:
  • Plau overexpression +20%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PLAU (9606)
  • PLAU (9615)
  • PLAU (9913)
  • Plau (10090)
  • Plau (10116)
  • PLAU (9031)

  • Inparanoids
  • ENSRNOP00000014273 (10116)
  • ENSMUSP00000022368 (10090)
  • ENSMUSP00000022368 (10090)



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