Denigma

pka1

Symbol: pka1
Name: cAMP-dependent protein kinase 1
Alias: tpk; git6
Entrez gene ID: 2539781
Ensembl gene ID: SPBC106.10
Species: (Taxid: 4896)

Functional description:
cAMP-dependent protein kinase catalytic subunit Pka1

Observation:

pka1 knockouts exhibits a three-fold increase in chronological lifespan with up to 187% longer maximum lifespan [16822282]. Deleting ser/thr cAMP-activated protein kinase pka1 extends chronological lifespan under normal condition, but there is no additive effect with DR [20075862].



Interventions:
  • pka1 deletion +300% +187%

    • Assays: Chronological Lifespan
    Mean: +300
    Maximum: +187

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PRKACB (9606)
  • PRKACB (9598)
  • PRKACB (9615)
  • PRKACB (9913)
  • Prkacb (10090)
  • Prkacb (10116)
  • PRKACB (9031)
  • prkacbb (7955)
  • Pka-C1 (7227)
  • AgaP_AGAP001384 (7165)
  • pka1 (4896)
  • TPK2 (4932)
  • KLLA0D03190g (28985)
  • AGOS_AFL090W (33169)
  • GeneID:2684523 (148305)
  • NCU06240 (5141)

    • Orthologs
  • Prkacb (10116)
  • Pka-C1 (7227)
  • TPK2 (4932)
  • Prkacb (10090)
  • PRKACB (9606)
  • Prkacb (10116)
  • Pka-C1 (7227)
  • TPK2 (4932)
  • Prkacb (10090)
  • PRKACB (9606)



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