Pou1f1

Symbol: Pou1f1
Name: POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
Alias: Pit1; Pit-1
Entrez gene ID: 18736
Ensembl gene ID: ENSMUSG00000004842
Species: Mouse (Taxid: 10090)

Functional description:
Transcription factor that regulates pituitary development; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'. [UniProt]

Observation:

Snell dwarf mutation (Pit1dw) due to knockout of Pou1f1 results in a dramatic lifespan extension. The mean, median and maximum lifespan is increased by 40-50% for Snell dwarf (Pit1dw/Pit1dw) DW/J females, and 25-50% for dwarf DWC3F1 males and females with a compound heterozygous Pit1dw/Pit1dw-J genotype. Although, Snell dwarf (Pit1dw/Pit1dw) DW/J males exhibit aspects of delayed senescence, their median lifespan is by about 25% shorter, probably due to the affects of housing conditions [11718806]. Mice homozygous for loss-of-function mutations at Pit1 locus have a mean and maximum lifespan extension over 40%. Mutant dwJ/dw animals exhibit delays in age-dependent collagen cross-linking and in six age-senstive indices of immune system status. Pituitary transplantation into dwarf mice does not reverse the lifespan extension effect. Male Snell dwarf mice become obese and exhibit proportionately high leptin levels in old age [11371619].



Interventions:
  • Pou1f1 knockout +25 to +50% +25 to +50% +25 to +50%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • POU1F1 (9606)
  • POU1F1 (9598)
  • POU1F1 (9615)
  • POU1F1 (9913)
  • Pou1f1 (10090)
  • Pou1f1 (10116)
  • POU1F1 (9031)
  • pou1f1 (7955)

  • Inparanoids
  • ENSRNOP00000000905 (10116)
  • ENSMUSP00000004964 (10090)
  • ENSMUSP00000004964 (10090)



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