pdk-1

Symbol: pdk-1
Name: PDK-class protein kinase
Entrez gene ID: 180475
Ensembl gene ID: H42K12.1
Species: Worm (Taxid: 6239)

Functional description:
Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. [UniProt]

Observation:

Loss-of-function alleles in pdk-1 extend lifespan by 60% [10364160].

pdk-1(sa680) mutants are dauer constitutive (suppressed by daf-16) and a gain of function allele can suppress age-1 dauer constitutive phenotype [10364160].



Interventions:
  • pdk-1 mutation +60%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PDPK1 (9606)
  • PDPK1 (9615)
  • PDPK1 (9913)
  • Pdpk1 (10090)
  • Pdpk1 (10116)
  • PDPK1 (9031)
  • pdpk1b (7955)
  • Pk61C (7227)
  • AgaP_AGAP001471 (7165)
  • pdk-1 (6239)
  • PDK1 (3702)
  • AT3G10540 (3702)
  • Os01g0872800 (4530)

  • Orthologs
  • PKH2 (4932)
  • PKH2 (4932)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit