Pcmt

Symbol: Pcmt
Name: Protein-L-isoaspartate (D-aspartate) O-methyltransferase
Entrez gene ID: 40668
Ensembl gene ID: FBgn0086768
Species: Fly (Taxid: 7227)

Functional description:
Protein carboxyl methyltransferase important for repair of abnormal protein aspartyl residues; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. [UniProt]

Observation:

Overexpression of Pcmt extends lifespan by 32-39% at 29 degrees but not at 25 degrees [11742076].

The adult lifespan of animals overexpressing Pcmt is extended [18772467].



Interventions:
  • Pcmt overexpression 0 to 39%

  • Assays: Organismal Lifespan
    Mean: 0 to +39

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 11742076: Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase.
  • 18772467: Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • LOC423008 (9031)
  • pcmtl (7955)
  • Pcmt (7227)
  • AgaP_AGAP000457 (7165)
  • PIMT1 (3702)
  • Os08g0557000 (4530)

  • Inparanoids
  • FBpp0078405 (7227)
  • ENSMUSP00000090386 (10090)
  • ENSRNOP00000050469 (10116)
  • ENSMMUP00000032338 (9544)
  • ENSP00000356354 (9606)
  • SPAC869.08 (4896)



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