Symbol: Pcmt Name: Protein-L-isoaspartate (D-aspartate) O-methyltransferase Entrez gene ID: 40668 Ensembl gene ID: FBgn0086768 Species: Fly (Taxid: 7227) Functional description: Protein carboxyl methyltransferase important for repair of abnormal protein aspartyl residues; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. [UniProt] Observation: Overexpression of Pcmt extends lifespan by 32-39% at 29 degrees but not at 25 degrees [11742076]. The adult lifespan of animals overexpressing Pcmt is extended [18772467]. Interventions: Assays: Organismal Lifespan Mean: 0 to +39 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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