BRE5

Symbol: BRE5
Name: BREfeldin A sensitivity 5
Entrez gene ID: 855787
Ensembl gene ID: YNR051C
Species: Yeast (Taxid: 4932)

Functional description:
Bre5p; Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A [Source:SGD;Acc:S000005334] [Ensembl]

Observation:

Deletion of BRE5 increases mean replicative lifespan by 30% [16293764] and mean chronological lifespan in diploid cells [21447998]



Interventions:
  • BRE5 deletion +30%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • BRE5 (4932)
  • KLLA0C18799g (28985)
  • AGOS_ABR118C (33169)



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