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Symbol: osm-6 Name: OSMotic avoidance abnormal Entrez gene ID: 179631 Ensembl gene ID: R31.3 Species: Worm (Taxid: 6239) Functional description: Required for dauer formation and recovery [Vowels and Thomas, 1992; Malone et al. 1996]; Protein OSM-6; OSMotic avoidance abnormal family member (osm-6) [Source:RefSeq peptide;Acc:NP_741633] [Ensembl]; osm-6 encodes a novel protein that is orthologous to the IFT52 component of the intraflagellar transport particle; osm-6 activity is required cell autonomously for proper sensory cilium structure and thus for normal ciliated sensory neuron function; OSM-6 is a component of the intraflagellar transport particle subcomplex B, and OSM-6::GFP reporter fusions are expressed exclusively in ciliated sensory neurons. [WormBase] Observation: Loss-of-function mutation in osm-6 increases lifespan by up to 40% [10617200]. osm-6 mutants are dauer-defective, chemotaxis defective [730048; 8348618], dye-filling defective [9475731], have extremly shortened axonemes, ectopic assembly of ciliary structures and microtubules in many sensory neurons [Perkins et al. 1986] Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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