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Symbol: nuo-2 Name: NADH Ubiquinone Oxidoreductase Entrez gene ID: 172363 Ensembl gene ID: T10E9.7 Species: Worm (Taxid: 6239) Functional description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).; Protein NUO-2; NADH Ubiquinone Oxidoreductase family member (nuo-2) [Source:RefSeq peptide;Acc:NP_871796] [Ensembl] Observation: RNA interference of nuo-2 extends lifespan [15998808]. RNAi against nuo-2 increases mean and maximum lifespan by 33 and 70%. RNAi of nuo-2 during larval stages is necessary and sufficient for increased lifespan, while RNAi only during adulthood fails to extend lifespan. daf-16 mutation fails to prevent lfiespan extension confered by nuo-2 RNAi, while mutation of daf-2 further extend the lifespan of nueo-2 RNAi animals [12471266]. nuo-2 RNAi causes reduced rate of growth to adulthood, reduced pharyngeal pumping, reduced body size, reduced ATP levels (by 60-80%), and reduced defecation and motility [12471266]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: nuo02 RNAi extends lifespan by 42% (Dillin et al. 2002) according to the Aging Intervention DB. Edit \ Update (Admin) | Delete |
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