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Symbol: nuo-1 Name: NADH Ubiquinone Oxidoreductase Entrez gene ID: 174696 Ensembl gene ID: C09H10.3 Species: Worm (Taxid: 6239) Functional description: Protein NUO-1; NADH Ubiquinone Oxidoreductase family member (nuo-1) [Source:RefSeq peptide;Acc:NP_496376] [Ensembl]; nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal. [WormBase] Observation: Mutations result in developmental arrest and increased lifespan. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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