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Symbol: bra-1 Name: BMP receptor Associated protein family Entrez gene ID: 181481 Ensembl gene ID: F54B11.6 Species: Worm (Taxid: 6239) Functional description: Protein BRA-1; BMP receptor Associated protein family member (bra-1) [Source:RefSeq peptide;Acc:NP_510277] [Ensembl]; The bra-1 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1) that negatively regulates the DAF-1/DAF-7/DAF-14 TGF-beta signalling pathway. BRA-1 is one of two C. elegans homologs of a human BMP receptor-associated molecule, BRAM1. BRA-1 interacts physically with the transforming growth factor-beta type I receptor DAF-1; the mutation bra-1(nk1) suppresses daf-1; and the bra-1 gene is coexpressed with daf-1 in amphid neurons such as ASK, ASI, and ASG. bra-1(nk1) also suppresses mutations in daf-7 and daf-14, and BRA-1 physically interacts with DAF-7 in vitro. bra-1 mutations have no effect on the phenotype of the null daf-1(e1287) mutation, or on that of the SMAD mutation daf-14(m77). BRA-1 has thus been proposed to exemplify a new class of proteins negatively regulating TGF-beta signalling by acting directly on the TGF-beta receptor. bra-1(nk1) homozygotes exhibit a 'head-lifting' phenotype. [WormBase] Observation: bra-1(nk1) mutation reduces mean lifespan by 6-25% [17900898]. Interventions: Assays: Organismal Lifespan Mean: -6 to -25 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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