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Symbol: npp-3 Name: Nuclear Pore complex Protein Entrez gene ID: 174823 Ensembl gene ID: K12D12.2 Species: Worm (Taxid: 6239) Functional description: Protein NPP-3; Nuclear Pore complex Protein family member (npp-3) [Source:RefSeq peptide;Acc:NP_496534] [Ensembl]; npp-3 encodes a nucleoporin that is a homolog of vertebrate Nup205; npp-3 is required for normal nuclear pore complex distribution in the nuclear envelope, nuclear exclusion of large non-nuclear macromolecules, chromatin condensation, proper mitotic spindle orientation, early embryonic viability, body integrity, and locomotion. [WormBase] Observation: RNA interference decreased median lifespan by 14% in wild type animals, 36% in a daf-2 background and 11% in daf-2/daf-16 double mutants. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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