Denigma

npp-2

Symbol: npp-2
Name: Nuclear Pore complex Protein
Entrez gene ID: 172611
Ensembl gene ID: T01G9.4
Species: Worm (Taxid: 6239)

Functional description:
Protein NPP-2; Nuclear Pore complex Protein family member (npp-2) [Source:RefSeq peptide;Acc:NP_492256] [Ensembl]; npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes. [WormBase]

Observation:

RNA interference decreased median lifespan by 11% in wild type animals, 38% in a daf-2 background and 22% in daf-2/daf-16 double mutants.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • NUP85 (9606)
  • NUP85 (9598)
  • NUP85 (9615)
  • NUP85 (9913)
  • Nup85 (10090)
  • Nup85 (10116)
  • NUP85 (9031)
  • pcnt1 (7955)
  • Nup75 (7227)
  • AgaP_AGAP012362 (7165)
  • npp-2 (6239)
  • AT4G32910 (3702)
  • Os01g0746200 (4530)



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