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Symbol: nnt-1 Name: Nicotinamide Nucleotide Transhydrogenase Entrez gene ID: 180884 Ensembl gene ID: C15H9.1 Species: Worm (Taxid: 6239) Functional description: Protein NNT-1; Nicotinamide Nucleotide Transhydrogenase family member (nnt-1) [Source:RefSeq peptide;Acc:NP_509028] [Ensembl]; nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. [WormBase] Observation: nnt-1 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 18% in wild type animals, 20% in daf-2 mutants and 16% in daf-2/gld-1 mutants. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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