nhx-2

Symbol: nhx-2
Name: Na/H eXchanger
Entrez gene ID: 174242
Ensembl gene ID: B0495.4
Species: Worm (Taxid: 6239)

Functional description:
Protein NHX-2; Na/H eXchanger family member (nhx-2) [Source:RefSeq peptide;Acc:NP_495614] [Ensembl]; nhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells. [WormBase]

Observation:

Gene inactivation by RNA interference led to a loss of fat stores in the intestine and a 40% increase in lifespan.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SLC9A3 (9606)
  • SLC9A3 (9913)
  • Slc9a3 (10090)
  • Slc9a3 (10116)
  • SLC9A3 (9031)
  • slc9a3.2 (7955)
  • slc9a3.1 (7955)
  • Nhe2 (7227)
  • AgaP_AGAP009036 (7165)
  • nhx-6 (6239)
  • nhx-9 (6239)
  • nhx-3 (6239)
  • nhx-2 (6239)



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