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Symbol: Bmcp Name: Mitochondrial uncoupler Alias: CG7314;DmBMCP;Dmel\CG7314;dmUCP5;DmUCP5;ucp5 Entrez gene ID: 39322 Ensembl gene ID: FBgn0036199 Species: Fly (Taxid: 7227) Functional description: CG7314 gene product from transcript CG7314-RB; Bmcp [Source:FlyBase gene name;Acc:FBgn0036199] [Ensembl]; The gene Bmcp is referred to in FlyBase by the symbol Dmel\Bmcp (CG7314, FBgn0036199). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: regulation of metabolic process. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Mitochondrial carrier domain; Mitochondrial carrier protein; Mitochondrial substrate/solute carrier. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [FlyBase] Observation: Bmcp knockout flies live longer on low-calorie diets, have a decreased fertility, and gain less weight on high-calorie diets. Bmcp (ucp5) knockout mutants live longer than wild-type on low-calorie diets, but no longer on starvation or high-calorie diets. Ectopic neuronal expression of Bmcp transgene rescues starvation sensitive phenotype of Bmcp knockout mutants [16387864]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Inparanoids Note: DR-Associated Gene Edit \ Update (Admin) | Delete |
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