NF1

Symbol: NF1
Name: Neurofibromin 1
Entrez gene ID: 43149
Ensembl gene ID: FBgn0015269
Species: Fly (Taxid: 7227)

Functional description:
Neurofibromin 1; Neurofibromin 1 [Source:FlyBase gene name;Acc:FBgn0015269] [Ensembl]; The gene Neurofibromin 1 is referred to in FlyBase by the symbol Dmel\Nf1 (CG8318, FBgn0015269). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Ras GTPase activator activity. There is experimental evidence for 14 unique biological process terms, many of which group under: biological regulation; response to stimulus; learning or memory; response to stress; system process; intracellular signal transduction; regulation of multicellular organismal process; cognition; cellular process; associative learning; determination of adult lifespan; growth; locomotory behavior; short-term memory. 37 alleles are reported. The phenotypes of these alleles are annotated with: pupa; wing disc; surface associated glial cell; heart primordium; eye photoreceptor cell; wing. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Armadillo-type fold; CRAL-TRIO domain; Ras GTPase-activating protein; Rho GTPase activation protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [FlyBase]

Observation:

NF1 mutants have a shortened lifespan and exhibited increased vulnerability to heat and oxidative stress as well as reduced mitochondrial respiration and elevated ROS production. Overexpression of NF1 increases mitochondrial respiration and reduced ROS production. It increases mean lifespan by 49% in males and 68% in females and maximum lifespan by 38% in males and 52% in females. It also improved reproductive fitness [17369827].



Interventions:
  • NF1 mutation
  • NF1 overexpression +49 to +68% +38 to +52%

  • Assays: Organismal Lifespan
    Mean: +49 to +68
    Maximum: +38 to +52

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • NF1 (9606)
  • NF1 (9598)
  • NF1 (9615)
  • Nf1 (10090)
  • Nf1 (10116)
  • NF1 (9031)
  • nf1a (7955)
  • Nf1 (7227)
  • AgaP_AGAP003140 (7165)
  • GeneID:5050582 (148305)
  • NCU01642 (5141)

  • Inparanoids
  • ENSMUSP00000071289 (10090)
  • ENSRNOP00000049106 (10116)
  • ENSMMUP00000011285 (9544)
  • ENSP00000351015 (9606)
  • YOL081W (4932)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit