bec-1

Symbol: bec-1
Name: BEClin (human autophagy) homolog 1
Entrez gene ID: 177345
Ensembl gene ID: T19E7.3
Species: Worm (Taxid: 6239)

Functional description:
Protein BEC-1; BEClin (human autophagy) homolog family member (bec-1) [Source:RefSeq peptide;Acc:NP_500844] [Ensembl]; bec-1 encodes a coiled-coil protein orthologous to the yeast and mammalian autophagy proteins Atg6/Vps30/Beclin1; by homology, BEC-1 may be part of a Class III phosphatidylinositol 3-kinase complex that plays a role in localizing autophagy proteins to preautophagosomal structures and overexpression of C. elegans bec-1 in S. cerevisiae APG6/VPS30 mutants can rescue associated autophagy defects; bec-1 is also required for regulation of endocytic retrograde transport; in C. elegans, bec-1 activity is required for normal dauer morphogenesis and survival of dauer larvae, as well as for adult life span extension of daf-2(e1370) mutants at 15 degrees; in addition, bec-1(RNAi) indicates a role for bec-1 in normal growth rates, movement, and vulval morphogenesis; a bec-1::GFP reporter fusion is expressed in the hypodermis, intestine, nervous system, pharynx, and reproductive organs, all tissues that are remodeled during dauer larval development; in vivo genetic evidence in C. elegans indicates that autophagy genes like bec-1, atg-7 and atg-18 protect cells from the accumulation of aggregates of polyglutamine expansion proteins which have been implicated in Huntington's disease and other neurodegenerative disorders. [WormBase]

Observation:

bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363].



Interventions:
  • bec-1 RNAi -14% -5%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • BECN1 (9606)
  • BECN1 (9598)
  • BECN1 (9913)
  • Becn1 (10090)
  • Becn1 (10116)
  • BECN1 (9031)
  • becn1 (7955)
  • Atg6 (7227)
  • AgaP_AGAP003858 (7165)
  • bec-1 (6239)
  • SPAC20G8.10c (4896)
  • VPS30 (4932)
  • KLLA0F01166g (28985)
  • AGOS_ACR154W (33169)
  • GeneID:2676971 (148305)
  • NCU03122 (5141)
  • AT3G61710 (3702)
  • Os03g0644000 (4530)
  • Os01g0681400 (4530)

  • Orthologs
  • VPS30 (4932)
  • SPAC20G8.10c (4896)
  • Becn1 (10090)
  • VPS30 (4932)
  • RGD1563293 (10116)
  • LOC715431 (9544)
  • Atg6 (7227)
  • BECN1 (9606)
  • BECN1 (9544)
  • Becn1 (10116)
  • VPS30 (4932)
  • SPAC20G8.10c (4896)
  • Becn1 (10090)
  • VPS30 (4932)
  • RGD1563293 (10116)
  • LOC715431 (9544)
  • Atg6 (7227)
  • BECN1 (9606)
  • BECN1 (9544)
  • Becn1 (10116)



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