mes-1

Symbol: mes-1
Name: Maternal Effect Sterile
Entrez gene ID: 181362
Ensembl gene ID: F54F7.5
Species: Worm (Taxid: 6239)

Functional description:
Protein MES-1; Maternal Effect Sterile family member (mes-1) [Source:RefSeq peptide;Acc:NP_741906] [Ensembl]; The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules. [WormBase]

Observation:

mes-1(bn7) mutant animals that lack germ cells live about 60% longer than fertile mes-1(bn7) controls. This lifespan extension requires daf-16 [11799246]. Homozygous mes-1 mutant progeny from homozygous mutant mothers are sterile [1783292].



Interventions:
  • mes-1 mutation

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • B0198.3 (6239)
  • mes-1 (6239)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit