MEC1

Symbol: MEC1
Name: Mitosis Entry Checkpoint 1
Alias: ESR1; SAD3; RAD31
Entrez gene ID: 852433
Ensembl gene ID: YBR136W
Species: Yeast (Taxid: 4932)

Functional description:
Involved in replication stress and DNA damage; Mec1p; Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination [Source:SGD;Acc:S000000340] [Ensembl]; Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres [SGD]

Observation:

MEC1 mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion [17710147].



Interventions:
  • MEC1 deletion

  • Assays: Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • rad3 (4896)
  • MEC1 (4932)
  • KLLA0C15785g (28985)
  • AGOS_ABR108C (33169)
  • GeneID:2682787 (148305)
  • NCU11188 (5141)



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