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Symbol: max-1 Name: Motor AXon guidance Entrez gene ID: 179794 Ensembl gene ID: C34B4.1 Species: Worm (Taxid: 6239) Functional description: Protein MAX-1; Motor AXon guidance family member (max-1) [Source:RefSeq peptide;Acc:NP_001041092] [Ensembl]; max-1 encodes a novel, conserved PH/MyTH4/FERM domain-containing protein; max-1 activity is required cell-autonomously in motor neurons for UNC-6-mediated, dorsally directed axon guidance, proper axon extension and axon fasciculation in the nerve cords, and fully normal backward locomotion; genetic analyses indicate that max-1 likely acts downstream of unc-6 and unc-5, and in parallel to unc-40 and unc-129, to regulate axon guidance; max-1 expression begins during later stages of embryogenesis and continues through adulthood; expression is seen in motor neurons that extend circumferential processes, other neurons and, for the short form of MAX-1, body wall muscles; in neurons, MAX-1 localizes to processes but is excluded from cell bodies in a manner dependent upon the FERM domain, which appears critical for MAX-1 function. [WormBase] Observation: RNA interference extended lifespan. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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