Denigma

lin-4

Symbol: lin-4
Name: abnormal cell LINeage 4
Entrez gene ID: 176068
Ensembl gene ID: K10B2.1
Species: Worm (Taxid: 6239)

Functional description:
Small noncoding temporal RNA that controls the timing of larval development; Controls the migration of neuroblasts and the subsequent mid-body region-specific development. [UniProt]

Observation:

A loss-of-function mutation in lin-4 shortens lifespan and accelerated tissue ageing while overexpressing lin-4 extends lifespan by redarding aging [16373574].

lin-4 is regulated by DAF-16 in L1 arrest.



Interventions:
  • lin-4 mutation
  • lin-4 overexpression

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


    • Type:
  • Gene
  • miRNA

    References:
  • 16373574: A developmental timing microRNA and its target regulate life span in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HOXC6 (9606)
  • Hoxc6 (10090)
  • Hoxc6 (10116)
  • hoxc6a (7955)
  • lin-39 (6239)



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