|
Symbol: cid-1 Name: (Caffeine Induced Death (S. pombe Cid) homolog 1 Alias: pup-1; cde-1 Entrez gene ID: 175707 Ensembl gene ID: K10D2.3 Species: Worm (Taxid: 6239) Functional description: Protein CID-1; Caffeine Induced Death (S. pombe Cid) homolog family member (cid-1) [Source:RefSeq peptide;Acc:NP_498099] [Ensembl]; cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases. [WormBase] Observation: RNA interference of cid-1 extends lifespan results in developmental abnormalities but also a significant increase in lifespan [16741121]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit