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Symbol: scrm-8 Name: SCRaMblase (phospholipid scramblase) 8 Entrez gene ID: 187152 Ensembl gene ID: K08D10.7 Species: Worm (Taxid: 6239) Functional description: Protein SCRM-8; SCRaMblase (phospholipid scramblase) family member (scrm-8) [Source:RefSeq peptide;Acc:NP_500501] [Ensembl]; scrm-8 encodes a putative phospholipid scramblase required for normally short lifespan; SCRM-8 is homologous to human PLSCR1-5, and paralogous to other C. elegans SCRMs (e.g., SCRM-1). Scramblase is activated by a rise of intracellular calcium, and promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis. Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell. [WormBase] Observation: RNA interference of scrm-8 extends lifespan [15998808]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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