jnk-1

Symbol: jnk-1
Name: Jun N-terminal Kinase
Entrez gene ID: 177460
Ensembl gene ID: B0478.1
Species: Worm (Taxid: 6239)

Functional description:
Responds to activation by environmental stress by phosphorylating a number of transcription factors, and thus regulates transcriptional activity (By similarity). May coordinate locomotion by acting via type-D GABAergic motor neurons and regulate synaptic vesicle transport in conjunction with unc-16. [UniProt]

Observation:

Overexpression of jnk-1 increases lifespan by 40% [15767565; 23097426].

JNK-1 overexpression extends the lifespan in a daf-16-dependent manner. JNK-1 directly phosphorylates DAF-16. JNK-1 overexpression does not extend the lifespan of animals unable to synthesize miRNAs, i.e. pash-1(mj100) [23097426].



Interventions:
  • jnk-1 overexpression +40%

  • Assays: Organismal Lifespan
    Mean: +40

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • References:
  • 15767565: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
  • 23097426: Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MAPK10 (9606)
  • MAPK10 (9598)
  • MAPK10 (9615)
  • MAPK10 (9913)
  • Mapk10 (10090)
  • Mapk10 (10116)
  • MAPK10 (9031)
  • mapk10 (7955)
  • bsk (7227)
  • AgaP_AGAP009461 (7165)
  • jnk-1 (6239)



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