Symbol: jnk-1 Name: Jun N-terminal Kinase Entrez gene ID: 177460 Ensembl gene ID: B0478.1 Species: Worm (Taxid: 6239) Functional description: Responds to activation by environmental stress by phosphorylating a number of transcription factors, and thus regulates transcriptional activity (By similarity). May coordinate locomotion by acting via type-D GABAergic motor neurons and regulate synaptic vesicle transport in conjunction with unc-16. [UniProt] Observation: Overexpression of jnk-1 increases lifespan by 40% [15767565; 23097426]. JNK-1 overexpression extends the lifespan in a daf-16-dependent manner. JNK-1 directly phosphorylates DAF-16. JNK-1 overexpression does not extend the lifespan of animals unable to synthesize miRNAs, i.e. pash-1(mj100) [23097426]. Interventions: Assays: Organismal Lifespan Mean: +40 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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