ife-2

Symbol: ife-2
Name: Initiation Factor 4E (eIF4E) family
Entrez gene ID: 180393
Ensembl gene ID: R04A9.4
Species: Worm (Taxid: 6239)

Functional description:
disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. [UniProt]

Observation:

Loss-of-function mutation in ife-2 reduces protein synthesis and increases maximum lifespan by about 20%. It does not extend the lifespan of daf-16(RNAi) animals. TOR/let-373 RNA interference further extends lifespan of ife-2 mutants. Reduction of protein synthesis increases ATP availability and stress resistance [17266679].



Interventions:
  • ife-2 mutation +20%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ife-5 (6239)
  • ife-1 (6239)
  • ife-2 (6239)



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