Symbol: ife-2 Name: Initiation Factor 4E (eIF4E) family Entrez gene ID: 180393 Ensembl gene ID: R04A9.4 Species: Worm (Taxid: 6239) Functional description: disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. [UniProt] Observation: Loss-of-function mutation in ife-2 reduces protein synthesis and increases maximum lifespan by about 20%. It does not extend the lifespan of daf-16(RNAi) animals. TOR/let-373 RNA interference further extends lifespan of ife-2 mutants. Reduction of protein synthesis increases ATP availability and stress resistance [17266679]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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