Hsp23

Symbol: Hsp23
Name: Heat shock protein 23
Entrez gene ID: 39077
Ensembl gene ID: FBgn0001224
Species: Fly (Taxid: 7227)

Functional description:
Heat shock protein 23; Heat shock protein 23 [Source:FlyBase gene name;Acc:FBgn0001224] [Ensembl]; The gene Heat shock protein 23 is referred to in FlyBase by the symbol Dmel\Hsp23 (CG4463, FBgn0001224). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: response to hypoxia. 26 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Alpha crystallin/Heat shock protein; HSP20-like chaperone; Heat shock protein Hsp20. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderate expression. Peak expression observed during late larval stages, at stages throughout the pupal period. [FlyBase]

Observation:

Overexpression of Hsp23 increases mean lifespan by more than 30% and increases the premortality phase [14734639].



Interventions:
  • Hsp23 overexpression +30%

  • Assays: Organismal Lifespan
    Mean: +30

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • Hsp26 (7227)
  • Hsp27 (7227)
  • Hsp23 (7227)
  • Hsp67Ba (7227)

  • Orthologs
  • hsp-12.6 (6239)
  • hsp-12.6 (6239)

  • Inparanoids
  • ENSRNOP00000014627 (10116)



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