hsp-16.1

Symbol: hsp-16.1
Name: Heat Shock Protein
Entrez gene ID: 179286
Ensembl gene ID: T27E4.8
Species: Worm (Taxid: 6239)

Functional description:
Protein HSP-16.1; Heat shock protein Hsp-16.1/Hsp-16.11 [Source:UniProtKB/Swiss-Prot;Acc:P34696] [Ensembl]; hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. In general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. [WormBase]

Observation:

Overexpression of the hsp-16 loci enhances stress resistance and extends mean lifespan by 11% at 20 degree Celsius. Lifespan extension by hsp-16 overexpression requires daf-16 [12882326].



Interventions:
  • hsp-16 overexpression +11%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • sip-1 (6239)
  • hsp-16.41 (6239)
  • hsp-16.49 (6239)
  • hsp-16.48 (6239)
  • F08H9.4 (6239)
  • hsp-16.11 (6239)
  • hsp-16.1 (6239)
  • F08H9.3 (6239)
  • hsp-16.2 (6239)

  • Orthologs
  • hsp-12.6 (6239)



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