hpk-1

Symbol: hpk-1
Name: Homeodomain interacting Protein Kinase
Entrez gene ID: 180695
Ensembl gene ID: F20B6.8
Species: Worm (Taxid: 6239)

Functional description:
Protein HPK-1; Homeodomain interacting Protein Kinase family member (hpk-1) [Source:RefSeq peptide;Acc:NP_741761] [Ensembl]; hpk-1 encodes a predicted dual-specificity protein kinase with distant homology to the vertebrate protein kinase DYRK1A and the Drosophila homolog mini-brain; increased expression of DYRK1A is implicated in the neuropathology of trisomy 21/Down syndrome; RNA interference of hpk-1 does not result in any detectable phenotype; the HPK-1::GFP fusion protein is localized to the nucleus and is expressed in cleavage stage embryos. [WormBase]

Observation:

RNA interference decreased median lifespan by 37% in wild type animals and 40% in daf-2 mutants.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • LOC572042 (7955)
  • LOC572323 (7955)
  • hpk-1 (6239)



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