Symbol: hpk-1 Name: Homeodomain interacting Protein Kinase Entrez gene ID: 180695 Ensembl gene ID: F20B6.8 Species: Worm (Taxid: 6239) Functional description: Protein HPK-1; Homeodomain interacting Protein Kinase family member (hpk-1) [Source:RefSeq peptide;Acc:NP_741761] [Ensembl]; hpk-1 encodes a predicted dual-specificity protein kinase with distant homology to the vertebrate protein kinase DYRK1A and the Drosophila homolog mini-brain; increased expression of DYRK1A is implicated in the neuropathology of trisomy 21/Down syndrome; RNA interference of hpk-1 does not result in any detectable phenotype; the HPK-1::GFP fusion protein is localized to the nucleus and is expressed in cleavage stage embryos. [WormBase] Observation: RNA interference decreased median lifespan by 37% in wild type animals and 40% in daf-2 mutants. Assays: Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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