HAT2

Symbol: HAT2
Name: Histone AcetylTransferase 2
Entrez gene ID: 856654
Ensembl gene ID: YEL056W
Species: Yeast (Taxid: 4932)

Functional description:
Hat2p; Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing [Source:SGD;Acc:S000000782] [Ensembl]

Observation:

HAT2 deletion mutants have an by 30% extended mean replicative lifespan. A hat2 mutant or a hat1hat2 double mutant, but not a hat1 mutant, have an extended lifespan [16023114].



Interventions:
  • HAT2 deletion +30%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HAT2 (4932)
  • KLLA0D00814g (28985)
  • AGOS_ACR017W (33169)
  • MSI3 (3702)
  • MSI2 (3702)
  • Os09g0540600 (4530)



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