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Symbol: Gpx4 Name: Glutathione peroxidase 4 Entrez gene ID: 625249 Ensembl gene ID: ENSMUSG00000075706 Species: Mouse (Taxid: 10090) Functional description: Protects cells against membrane lipid peroxidation and cell death. Isoform mitochondrial is required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. [UniProt] Observation: Heterozygous knockouts have a 7% increase in median lifespan. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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