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Symbol: GPA2 Name: G Protein Alpha subunit 2 Alias: SSP101 Entrez gene ID: 856741 Ensembl gene ID: YER020W Species: Yeast (Taxid: 4932) Functional description: Gpa2p; Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000000822] [Ensembl] Observation: Deletion of GPA2 increases mean and maximum replicative lifespan by 40% and 26%, respectively [11000115]. Deletion of GPA2 extends replicative lifespan by reducing cAMP-PKA activity and provides a genetic model for DR [11000115]. Interventions: Assays: Replicative Lifespan Mean: +40 Maximum: +26 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Note: Deletion increases lifespan by about 50% (Lin et al. 2000) arcording to Ageing intervention DB. Edit \ Update (Admin) | Delete |
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