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Symbol: glp-1 Name: abnormal Germ Line Proliferation Entrez gene ID: 176286 Ensembl gene ID: F02A9.6 Species: Worm (Taxid: 6239) Functional description: Receptor for a germ-line proliferation signal that is produced by the distal tip cells of the somatic gonad; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment the dorsal-ventral axis in early embryos. [UniProt] Observation: glp-1(qu158) mutations result in defects in germ-line proliferation and extension of lifespan by about 30%, which requires daf-16 [11799246]. glp-1(bn18) mutation increases mean, median, 75th %ile and maximum lifespan by 27-37, 26-33, 24-29 and 35%, respectively [22560223]. glp-1(e2141) mutation increases mean (32%) and maximum (53%) lifespan [18828672]. Two alleles of glp-1 that cause overproliferation of gemrline cells, glp-1(oz112gf) and glp-1(q485), result in a shortened lifespan [11799246]. In glp-1 mutants, Z2 and Z3 generate only a few germ cells, which enter meiosis and differentiate as sperm [3677168]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: Check out the lifespan decreasing allelels. how strongly are the effecting lifepsan, etc. Edit \ Update (Admin) | Delete |
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