Ghr

Symbol: Ghr
Name: Growth hormone receptor
Alias: GHBP
Entrez gene ID: 14600
Ensembl gene ID: ENSMUSG00000055737
Species: Mouse (Taxid: 10090)

Functional description:
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. [UniProt]

Observation:

Ghr knockouts (the so called Laron mice) are dwarfs with significantly extended lifespan by 40-50% [12933651]. Ghr-/- mice are significantly longer lived as Ghr+/+ or Ghr+/- mice (by 40-50%) in both females and males [10875265; 19370397]. 30% DR fails to affect overall survival, average or median long-lifespan of Growth hormone receptor knockout (GHRKO) mice and increased maximal lifespan only in females. Insulin sensitivity in GHRKO mutants is greater than in wild-type and is not further increased by DR [16682650]. Intermittent fasting also fails to extend the long lifespan of GHRKO mice [19747233]. Lifespan of mice with a deletion in the Ghr gene live almost 5 years [21123740]. In C57BL/6J this mutation increases life expectancy by 16 to 26% depending on gender [12933651] and in mice of mixed genetic background the increases amounted to 36-55% [9371826]. Serum levels of GH are elevated in mutant mice [9371826] and mutants are smaller than wild-type. IGF-1 and IGFBP-3 levels are also reduced in Ghr mutant mice [10875265]. The age-associated decline in memory retention is delayed in Ghr mutants [11336996]. Overexpression of a growth hormone antagonist (a mutated growth hormone that competes with the endogenous one) has no effect on lifespan [12933651].



Interventions:
  • Ghr knockout +16 to +55%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


  • References:
  • 22484922: Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • GHR (9606)
  • GHR (9598)
  • GHR (9615)
  • GHR (9913)
  • Ghr (10090)
  • Ghr (10116)
  • GHR (9031)
  • ghra (7955)

  • Orthologs
  • GHR (9606)
  • Ghr (10116)
  • GHR (9544)
  • GHR (9606)
  • Crlf1 (10090)
  • Prlr (10090)
  • Ghr (10116)
  • GHR (9544)

  • Inparanoids
  • ENSRNOP00000044119 (10116)
  • ENSMUSP00000069457 (10090)
  • ENSMUSP00000069457 (10090)

  • Note: In Ref 9371826 there is nothing about lifespan (The information was from the RoSyBA symposium report). There is a discripance in the lifespan extension reported by 12933651.

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