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Symbol: GCN5 Name: General Control Nonderepressible 5 Entrez gene ID: 853167 Ensembl gene ID: YGR252W Species: Yeast (Taxid: 4932) Functional description: Gcn5p; Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase comple /.../ounding member of the Gcn5p-related N-acetyltransferase superfamily; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000003484] [Ensembl]; Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay [SGD] Observation: Deletion of GCN5 decreases replicative lifespan of extension of rho+ and rho0 cells as well as suppresses lifespan extension by the retrograde response [15547318]. Deletion of GCN5 strongly reduces chronological lifespan [19801973]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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